With the rapid development of the national economy, higher requirements have been put forward on the fineness, purity and crushing equipment of various powders including medicinal powder. Superfine pulverization is very important for drugs, which will affect its efficacy and absorption in the body. The current market demand for micronized solid medicines is increasing year by year.

In the pharmaceutical process, ultra-fine powder drugs are usually obtained through micro-powder crystallization and ultra-fine grinding. Micropowder crystallization is obtained by preparing ultrafine crystals by controlling the crystallization process conditions, and then filtering, washing, draining and drying. Ultrafine grinding is obtained by ultrafine grinding of crystal particles obtained by crystallization of large particles. At present, the ultra-fine grinding process is widely used by manufacturers. In view of the characteristics of ultra-fine medicines with fine particle size, high quality and strong purification ability, the machinery suitable for ultra-fine medicine grinding mainly includes mechanical impact mills, ball mills, vibration mills, and stirring. Mill, two-way rotating ball mill, jet mill, etc. This article mainly introduces the application of jet mill and the price of jet mill.

Jet mill is a kind of equipment that accelerates compressed air or inert gas through nozzles, and uses the energy of high-speed elastic fluid or superheated steam to make particles, gases and particles, particles and walls and other components produce strong impact, shear, collision and friction. At the same time, the coarse and fine particles are classified under the action of the air rotating centrifugal force or the combined action of the classifier to realize ultra-fine crushing. As a commonly used powder preparation method, the jet mill is not expensive and is suitable for pulverizing heat-sensitive drugs such as antibiotics, enzymes, and low melting points.

Because the jet mill uses gas as kinetic energy to achieve pulverization, its pulverization mechanism is different from other mechanical equipment. Specifically, the particle size distribution range is narrow, and the average particle size is fine. In the crushing process, due to the centrifugal force of the high-precision classifier, the coarse and fine particles are automatically classified, and the obtained product has a narrow particle size distribution, a fine average particle size, a good powder shape, and a high product purity. The powder prepared by the jet mill tends to be "spherical", the particle surface is smooth, the shape is regular, the dispersion is good, the mechanical abrasion during the grinding process is small, and the product purity is high. A jet mill suitable for low-melting, heat-sensitive drugs. It is powered by compressed air. The compressed air jets the air at a high speed to produce the Joule-Thomson effect. The air collides at the nozzle adiabaticly, thereby reducing the temperature of the crushing system and counteracting drug collisions. Heat from friction. The ambient temperature in the crushing chamber can reach tens of degrees below zero, which is suitable for preparing low-melting, heat-sensitive drugs. Good air tightness and no pollution. Due to the air-tightness of the jet mill, the product yield is high; the whole crushing process is carried out under negative pressure, the crushing will not leak, it does not pollute the environment, and can be operated under aseptic conditions.

Although jet mills are not expensive, jet mills also have disadvantages. For example, jet mills have lower energy utilization, higher energy consumption, and higher production costs than ball mills and other mechanical crushing. During the crushing process, the volatile components are easily taken away by the high-speed airflow, resulting in the loss of the effective ingredients of the medicine. Due to the nature of jet mills, the output of jet mills is generally small.