More and more attention has been paid to the air jet pulverization of raw materials. Air jet pulverization can improve the bioavailability and bioequivalence, and control the dissolution rate. However, there are various jet mills in the industry, and the prices of various jet mills are different. Which jet mill is better?

Since the production capacity is related to the fineness of raw materials and the requirements for fineness after crushing, when purchasing equipment, in addition to considering the price of jet mills, it is best to consider the relationship between batch size and equipment. The finer the crushing, the lower the output and the slower the speed. If the batch is about 5-20g at a time, J-20 jet mill can be considered. Since the diameter of the J-20 jet mill is only 4 cm, the amount of crushed materials is small, and the collection rate of materials is also high. It takes about 0.5 hours to crush 5 grams of material, which of course depends on the nature of the material. The basic operation idea is to use the fastest feed rate to ensure the highest crushing efficiency under the premise of ensuring the crushing particle size. If the batch is about 50 grams, you can consider the J-25 type, if the batch is about 100 grams, you can consider the J-30 type.

The production jet mill can be set according to the batch size of the medicine. Some medicines are relatively small in size, perhaps only a few hundred grams. As the medicine is relatively expensive, smaller equipment should be used as much as possible, because the smaller jet mill is relatively cheap, which can increase the collection rate and avoid the large loss of viscous substances to the medicine. For example, for the production of aerosols, J-20, 30, 40, 50 equipment and other products can be considered as production equipment, with compact structure, small material contact area, and low loss of viscous materials, which are very popular with customers.

Of course, for most customers, we will still consider large-scale production equipment, such as a few kilograms, tens of kilograms or even hundreds of kilograms per hour. Large-scale equipment may face more problems than small-scale equipment. The first is the price factor of the equipment selection jet mill. Because as a large-scale equipment, two adjacent models can be selected to adjust the production capacity through the crushing time. The premise is that the material is crushed well. It is better to achieve without blocking. However, the current pharmaceutical industry generally faces the problem of poor crushing process:

Venturi clogging is a common problem in the medicine crushing industry. Due to the influence of solvents and impurities, during the process of spraying the materials through the venturi onto the crushing plate, the medicine will slowly attach a layer of film to the venturi hole, and then the film will become thicker and thicker until the venturi mouth is blocked. , Unable to feed materials for crushing production. At present, the manufacturer that can solve this clogging problem is an Italian company, but the premise is that the material must be tested to ensure that if a batch of materials is 9 kg, then we will adopt a 9 kg solution to ensure that the material is pressed to 9 kg. Will not block. If it is 20 kg, use another solution.

Some companies use induced draft fans and pulse blowback to collect materials. This structure will cause materials to accumulate in the vertebral body after entering the vertebral body, affecting the crushing process. The Italian jet mill adopts a special design, so this will not happen. The material will fall directly from the inside of the filter bag to the outlet in the middle of the bottom cyclone, which will not cause the material to stick to the edge of the vertebral body and cause trouble to the customer.